16th Annual Scientific Sessions:

16th Annual Scientific Sessions:

16th Annual Scientific Sessions:

Using unbiased discovery approaches for identifying novel mechanisms modulating cardiovascular metabolism

Using unbiased discovery approaches for identifying novel mechanisms modulating cardiovascular metabolism

Using unbiased discovery approaches for identifying novel mechanisms modulating cardiovascular metabolism

Isle of Palms, Charleston, SC, USA • September 30 – October 3, 2018

Isle of Palms, Charleston, SC, USA
September 30 – October 3, 2018

Isle of Palms, Charleston, SC, USA
September 30 – October 3, 2018

 

Preliminary Program

  • Sunday, September 30

    3:00-5:00 p.m.

    Trainee Workshop      [Tides Ballroom]
    Systems approaches to biological discovery: from experimental design to data analysis and beyond
    This workshop format will include 15-minute talks by panelists, followed by panel discussion and attendee question and answer period on technical considerations and data analysis for ‘big data’ approaches.

     

    Panelists:
    Peipei Ping (University of California, Los Angeles, CA, USA)
    Exploring Knowledge Databases
    Jennifer Van Eyk (Cedars-Sinai Medical Center, Los Angeles, CA, USA)
    Proteomics and data analysis
    Tom Vondriska (University of California, Los Angeles, CA, USA)
    Generating and analyzing epigenetics data

    3:00-6:00 p.m.

    Registration     [Palms Foyer]

    Opening Session     [Tides Ballroom]

    5:30-5:45 p.m.

    Opening Remarks

    5:45-6:45 p.m.

    Keynote Lecture I
    Chair: L. Ashley Cowart (Virginia Commonwealth University, Richmond, VA, USA)
    Jennifer Van Eyk (Cedars-Sinai Medical Center, Los Angeles, CA, USA)
    How cool is proteomics? Impact on understanding cardiac metabolism

    7:00-10:00 p.m.

    Welcome Reception and Dinner     [Grand Pavilion]

  • Monday, October 1

    7:00-8:00 a.m.

    Breakfast      [Palmetto Hall]

    Session I — Metabolomics approaches to cardiometabolic disease      [Tides Ballroom]
    Chairs: Martin Young (University of Alabama Birmingham, Birmingham, AL, USA) and Jan Glatz (Maastricht University, Maastricht, Netherlands)

    8:00-8:30 a.m.

    Julian Griffin (King’s College, Cambridge, UK)
    Metabolomics and proteomics strategies to investigate cardiometabolic disease

    8:30-9:00 a.m.

    Blandine Comte (Université Clermont Auvergne, Clermont-Ferrand, France)
    Systems metabolomics: a way to go beyond phenotypes for disease molecular reclassification?

    9:00-9:15 a.m.

    Short talk: Yuan Zhang (University of Iowa, Iowa City, IA, USA)
    Untargeted metabolomics analysis identifies a-hydroxyglutarate as a signature of human heart failure

    9:15-9:30 a.m.

    Short talk: Maxime Tremblay-Gravel (Montreal, QC, Canada)
    Lipidomic analyses show distinct perturbations in fatty acid metabolism in patients with pulmonary hypertension due to left heart disease

    9:30-10:00 a.m.

    Paul Brookes (University of Rochester Medical Center, Rochester, NY, USA )
    Succinate in cardiac ischemia—friend or foe?

    10:00-10:30 a.m.

    Coffee break     [Tides Foyer]

    Session II — Epigenetic control of cardiac metabolism      [Tides Ballroom]
    Chairs: Jaetaek Kim (Chung-Ang University, Seoul, South Korea) and Linda Peterson (Washington University, St. Louis, MO, USA)

    10:30-11:00 a.m.

    Tom Vondriska (University of California, Los Angeles, CA, USA)
    Epigenomics of cardiovascular health and disease

    11:00-11:30 a.m.

    Don Menick (Medical University of South Carolina, Charleston, SC, USA)
    HDAC dependent regulation of mitochondrial metabolism

    11:30-11:45 a.m.

    Short talk: Eric Weatherford (University of Iowa, Iowa City, IA, USA)
    Insulin receptor substrate 1 controls inflammatory gene expression signatures in the heart after pressure overload

    11:45 a.m.-12:00 p.m.

    Short talk: Sander Houten (Icahn School of Medicine at Mount Sinai, New York, NY, USA)
    The transcriptional profile of hearts from the long-chain acyl-CoA dehydrogenase KO mouse

    12:00-12:30 p.m.

    Peipei Ping (University of California, Los Angeles, CA, USA)
    Decoding OPTM regulation of the mitochondrial proteome: a machine learning approach

    12:30-1:30 p.m.

    Working Lunch sponsored by QIAGEN      [Tides Ballroom]

    Jean-Noel Billaud (QIAGEN Bioinformatics, Redwood City, CA, USA)
    Helping you uncover new insights in heart development and disease with OmicSoft Array Studio and Ingenuity Pathway Analysis

    1:30-4:00 p.m.

    Free time

    The "William C. Stanley" Early Investigator Awards     [Tides Ballroom]

    4:00-4:15 p.m.

    Bruno Lefort (University Hospital of Tours, Tours, France)
    Unravelling the causes of arrhythmias in very-long chain acyl-CoA (VLCAD) deficiency through the combined use of non-targeted lipidomic and molecular analyses in a mouse model

    4:15-4:30 p.m.

    Golam Mezbah Uddin (University of Alberta, Edmonton, AB, Canada)
    Impaired insulin signalling in failing heart can be protected by enhancing branched chain amino acids (BCAA) catabolism

    4:30-4:45 p.m.

    Natasha Fillmore (NHLBI/NIH, Bethesda, MD, USA)
    A knock-in mutation at a site of S-nitrosylation on TRIM72 (TRIM72-C144S) is cardioprotective and improves insulin sensitivity

    4:45-5:00 p.m.

    Sobuj Mia (University of Alabama at Birmingham, Birmingham, AL, USA)
    The transcription factor REV-ERBα: a novel regulator of cardiac glycogen metabolism

    5:00-7:30 p.m.

    Poster Session I      [Palmetto Hall]

    7:30 p.m.

    Dinner     [Palms 1-5]

  • Tuesday, October 2

    7:00-8:00 a.m.

    Breakfast      [Palmetto Hall]

    8:00-9:00 a.m.

    Keynote Lecture II      [Tides Ballroom]
    Chair: Christine Des Rosiers (Université de Montréal, Montreal, QC, Canada)
    J. Mark Brown (Case Western Reserve University, Cleveland, OH, USA)
    Small molecule inhibition of gut microbial enzymes as a therapeutic strategy in cardiometabolic disease

    Session III — Proteomics      [Tides Ballroom]
    Chairs: Adam Wende (University of Alabama Birmingham, Birmingham, AL, USA) and Miranda Nabben (Maastricht University, Maastricht, Netherlands)

    9:00-9:30 a.m.

    John Chatham (University of Alabama Birmingham, Birmingham, AL, USA)
    O-GlcNacylation and cardiac metabolism

    9:30-10:00 a.m.

    Rui-Ping Xiao (Peking University, Beijing, China)
    Discovery of MG53 as a regulator of cardiovascular signaling

    10:00-10:15 a.m.

    Short talk: Aaron Olson (University of Washington, Seattle, WA, USA)
    The effect of glucose availability on myocardial hexosamine biosynthesis pathway (HBP) flux and protein O-GlcNAc levels

    10:15-10:45 a.m.

    Coffee break     [Tides Foyer]

    10:45-11:15 a.m.

    Elizabeth Murphy (National Institute of Heart, Lung, and Blood disorders, Bethesda, MD, USA)
    Using large-scale proteomics to discover novel mechanisms of cardioprotection

    11:15-11:30 a.m.

    Short talk: Veronique Lacombe (Oklahoma State University, Stillwater, OK, USA)
    The novel role of the sarcoplasmic reticulum calcium ATPase pump in regulating glucose homeostasis in healthy and diabetic state

    11:30-11:45 a.m.

    Short talk: Helen Collins (University of Alabama at Birmingham, Birmingham, AL, USA)
    Lack of cardiomyocyte stromal interaction molecule 1 (STIM1) recapitulates the metabolic phenotype of the diabetic heart

    12:00-1:00 p.m.

    Lunch      [Palmetto Hall]

    1:00-3:30 p.m.

    Poster Session II      [Palmetto Hall]

    4:30 p.m.

    Departure for tour of Historic Charleston and Gala Dinner

  • Wednesday, October 3

    7:00-8:00 a.m.

    Breakfast      [Palmetto Hall]

    8:00-9:00 a.m.

    "William C. Stanley" Award Lecture      [Tides Ballroom]
    Gary Lopaschuk (University of Alberta, Edmonton, AB, Canada)
    Why is there still confusion about energetics in the failing heart?

    Session IV - Insights into vascular metabolism      [Tides Ballroom]
    Chairs: Florin Despa (University of Kentucky, Lexington, KY, USA) and Michael Sack (National Heart, Lung, and Blood Institute, Bethesda, MD, USA)

    9:00-9:30 a.m.

    Zoltan Arany (University of Pennsylvania, Philadelphia, PA, USA)
    Vascular transport of fat by branched chain amino acid metabolites

    9:30-10:00 a.m.

    Christophe Beauloye (Université catholique de Louvain, Brussels, Belgium)
    Metabolic control of platelets: insights from metabolomics

    10:00-10:15 a.m.

    Short talk: Magdalena Zabielska (Medical University of Gdansk, Gdansk, Poland)
    4-pirydone-3-carboxamide-1β-D-ribonucleoside (4PYR) – a novel endogenous endothelial toxin that disrupts cellular energetics

    10:15-10:30 a.m.

    Short talk: Linda Peterson (Washington University, St. Louis, MO, USA)
    Ceramide remodeling and risk of cardiovascular events and mortality

    10:30-11:00

    Coffee break      [Tides Foyer]

    Session V - Mitochondrial metabolism      [Tides Ballroom]
    Chairs: Heiko Bugger (University Heart Center Frieburg, Bad Krozingen, Germany) and Coert Zuurbier (University of Amsterdam, Amsterdam, Netherlands)

    11:00-11:30 a.m.

    Jin Han (Inje University, Busan, South Korea)
    Pharmacological and genetic rescue of mitochondria during heart failure

    11:30-11:45 a.m.

    Short talk: Michael Portman (University of Washington, Seattle, WA, USA)
    The hypertrophied right ventricle displays impaired metabolic flexibility during tachycardia induced stress

    11:45 a.m-12:15 p.m.

    Mary-Ellen Harper (University of Ottawa, Ottawa, ON, Canada)
    Glutathione and glutaredoxin-2 in cardiac mitochondrial structure and function

    12:15-12:30 p.m.

    Concluding Remarks from SHVM chair and Introduction to 2019 Meeting      [Tides Ballroom]

    12:30 p.m.

    Boxed Lunch     [Palmetto Hall]

  • Posters

    When preparing your poster, please remember that its maximum size is 4 x 6 feet (1.2 x 1.8 m), height x width. Note that the orientation is landscape, not portrait.

    Correct format... poster should be LANDSCAPE  poster should NOT be PORTRAIT Wrong format...

    All posters should stay up for the entire duration of the meeting, independently of the session to which they have been assigned. You are kindly invited to put up your poster upon arrival, from Sunday evening onwards, and in time for the first poster session. Posters should be taken down only at the end of the meeting.

    Poster presenters are required to be available for discussion during their assigned session. The distribution of posters in the two sessions is indicated below.

    • Poster Session 1

      Monday, October 1 • 5:00-6:00 p.m.

      P1.1 · Tariq R. Altamimi (Edmonton, AB, Canada)
      A novel role of endothelial autophagy as a regulator of myocardial fatty acid oxidation

      P1.2 · Heiko Bugger (Freiburg, Germany)
      SIRT5 modulates myocardial ischemia reperfusion injury

      P1.3 · Laurent Bultot (Woluwe Saint-Lambert, Belgium)
      Role of protein acetylation in the inhibition of cardiac glucose uptake by fatty acids

      P1.4 · Helen E. Collins (Birmingham, AL, USA)
      Lack of cardiomyocyte stromal interaction molecule 1 (STIM1) recapitulates the metabolic phenotype of the diabetic heart

      P1.5 · Manon Denis (Nantes, France)
      O-GlcNAc level variation with age, impact of suckling to weaning transition

      P1.6 · Natasha Fillmore (Bethesda, MD, USA)
      A knock-in mutation at a site of S-nitrosylation on TRIM72 (TRIM72-C144S) is cardioprotective and improves insulin sensitivity

      P1.7 · Johannes Gollmer (Freiburg, Germany)
      Impaired systemic glucose homeostasis but preserved cardiac function in high-fat fed mice overexpressing SIRT4

      P1.8 · William Hancock (Richmond, VA, USA)
      Ceramides impact in diabetic cardiomyopathy

      P1.9 · Bradford G. Hill (Louisville, KY, USA)
      Stable isotope metabolomics under controlled metabolic states

      P1.10 · Sander M. Houten (New York, NY, USA)
      The transcriptional profile of hearts from the long-chain acyl-CoA dehydrogenase KO mouse

      P1.11 · Jaetaek Kim (Seoul, South Korea)
      The role of IGF-1 signaling in injury-induced cardiac fibrosis

      P1.12 · Veronique Lacombe (Stillwater, OK, USA)
      Insulin dysregulation is a major contributor to atrial fibrillation in diabetic mice

      P1.13 · Terje S. Larsen (Tromsø, Norway)
      Cardioprotective effect of Calanus oil in hearts from diet-induced female mice exposed to ischemia-reperfusion

      P1.14 · Bruno Lefort (Tours, France)
      Unravelling the causes of arrhythmias in very-long chain acyl-CoA (VLCAD) deficiency through the combined use of non-targeted lipidomic and molecular analyses in a mouse model

      P1.15 · Edward J. Lesnefsky (Richmond, VA, USA)
      Mitochondria Associated Membranes: a target of injury during early reperfusion

      P1.16 · Byung Kwan Lim (Goesan-gun, South Korea)
      Cardiac conduction system specific CAR deletion induced SA and AV-node dysfunction

      P1.17 · Alice Marino (New York, NY, USA)
      Nogo-A/B inhibits sphingolipid de novo biosynthesis in cardiomyocytes to protect the heart from failure

      P1.18 · Lauriane Y.M. Michel (Brussels, Belgium)
      Cardiac myocyte-specific expression of beta3-adrenergic receptors promotes glucose uptake in myocardial hypertrophic remodeling

      P1.19 · Katie A. O'Brien (Cambridge, United Kingdom)
      Hypoxic exposure modifies the cardiac metabolic response to mitochondrial complex III inhibition

      P1.20 · Yongseek Park (Seoul, South Korea)
      Effect of crotonaldehyde on autophagy-mediated cytotoxicity in human endothelial cells

      P1.21 · Linda R. Peterson (Saint Louis, MO, USA)
      Ceramide remodeling and risk of cardiovascular events and mortality

      P1.22 · Michael A. Portman (Seattle, WA, USA)
      The hypertrophied right ventricle displays impaired metabolic flexibility during tachycardia induced stress

      P1.23 · Mohammed Quader (Richmond, VA, USA)
      Does early inhibition of inflammasome adds to the cardioprotection as seen with inflammasome blocker given at reperfusion in donation after circulatory death heart

      P1.24 · Matthieu Ruiz (Montreal, QC, Canada)
      Lipidomics unveils a peroxisomal metabolic connexion between liver and heart in hepatic steatosis

      P1.25 · Michael Schwarzer (Jena, Germany)
      High fat diet causes skeletal muscle mitochondrial alterations comparable to those in pressure overload induced heart failure

      P1.26 · Alicja Bulinska (Gdansk, Poland)
      Analysis of cardiac mitochondrial function in genetic model of dyslipidemia in mice

      P1.27 · Stefano Toldo (Richmond, VA, USA)
      Cardio-protection of LDL-receptor-Related Protein 1 agonist in mice with diet-induced obesity

      P1.28 · Golam Mezbah Uddin (Edmonton, AB, Canada)
      Impaired insulin signalling in failing heart can be protected by enhancing branched chain amino acids (BCAA) catabolism

      P1.29 · Eric T. Weatherford (Iowa City, IA, USA)
      Insulin receptor substrate 1 controls inflammatory gene expression signatures in the heart after pressure overload

      P1.30 · Coert J. Zuurbier (Amsterdam, Netherlands)
      Empagliflozin effects on ischemic contracture and ischemia reperfusion injury in isolated mouse hearts perfused with or withour insulin

      P1.31 · Li Lai (Houston, TX, USA)
      A glycolytic switch is required for transdifferentiation to endothelial lineage

    • Poster Session 2

      Tuesday, October 2 • 4:30-5:30 p.m.

      P2.1 · Sylvain Battault (Brussels, Belgium)
      Contribution of SGLT1 in cardiac glucose uptake

      P2.2 · Laurent Bultot (Woluwe Saint-Lambert, Belgium)
      Inhibiting O-GlcNAcylation by AMP-activated protein kinase, a new way to reverse cardiac hypertrophy development?

      P2.3 · Christopher J. Clarke (Stony Brook, NY, USA)
      A role for neutral sphingomyelinase-2 in doxorubicin-induced cardiotoxicity

      P2.4 · Zachary S. Cutter (Richmond, VA, USA)
      Effects of the Na-Cl co-transporter in western diet induced metabolic and cardiac dysfunction

      P2.5 · Manon Denis (Nantes, France)
      O-GlcNAc stimulation, a new hope for sepsis in the young population?

      P2.6 · Roselle Gélinas (Montreal, QC, Canada)
      Nitric oxide synthase 1 accessory protein (NOS1AP), a new long QT syndrome (LQTS) gene

      P2.7 · Chae-Myeong Jenna Ha (Birmingham, AL, USA)
      Roles of isoform specific pyruvate dehydrogenase kinases (PDKs) in modulating cardiac adaptations to heart failure

      P2.8 · Estelle Heyne (Jena, Germany)
      Female rats are running faster than their male counterparts despite reduced mitochondrial function

      P2.9 · Bradford G. Hill (Louisville, KY, USA)
      Myocardial infarction regulates prolidase activity and promotes insulin-mediated collagen remodeling  in the heart

      P2.10 · Hyoung Kyu Kim (Busan, South Korea)
      Myocardial Infarction targeting drug, Histochrome, enhances cardiomyocyte differentiation from mouse embryonic stem cells through PKCiota regulation

      P2.11 · Christoph Koentges (Freiburg, Germany)
      SIRT4 deficiency decreases myocardial ischemia reperfusion injury

      P2.12 · Veronique Lacombe (Stillwater, OK, USA)
      The novel role of the sarcoplasmic reticulum calcium ATPase pump in regulating glucose homeostasis in healthy and diabetic state

      P2.13 · Mary N. Latimer (Birmingham, AL, USA)
      The cardiomyocyte circadian clock impacts BCAA-induced cardiac growth

      P2.14 · Edward J. Lesnefsky (Richmond, VA, USA)
      Increased mitochondrial ROS generation from complex III causes mitochondrial damage and increased endoplasmic reticulum stress

      P2.15 · Edward J. Lesnefsky (Richmond, VA, USA)
      Modulation of electron transport by metformin in cardiac protection: role of complex I

      P2.16 · Ross T. Lindsay (Cambridge, United Kingdom)
      Isoprenaline unexpectedly protects mitochondrial function and conserves energetics in the type-1 diabetic heart

      P2.17 · Sobuj Mia (Birmingham, AL, USA)
      The transcription factor REV-ERBα: A novel regulator of cardiac glycogen metabolism

      P2.18 · Tien Dung Nguyen (Jena, Germany)
      Metabolic modulation in heart failure - A systematic review and meta-analysis of preclinical studies

      P2.19 · Aaron Olson (Seattle, WA, USA)
      The effect of glucose availability on myocardial hexosamine biosynthesis pathway (HBP) flux and protein O-GlcNAc levels

      P2.20 · Mark E. Pepin (Birmingham, AL, USA)
      Impact of patient race and diabetes on cardiac metabolic gene expression in end-stage human heart failure

      P2.21 · Katharina Pfeil (Freiburg, Germany)
      Lack of SIRT5 accelerates the development of heart failure following transverse aortic constriction

      P2.22 · Estelle Pujos-Guillot (Saint-Genès-Champanelle, France)
      Input of multidimensional phenotyping in the metabolic syndrome stratification

      P2.23 · Ravichandran Ramasamy (New York, NY, USA)
      Aldose reductase impairs autophagy during cardiac ischemia-reperfusion

      P2.24 · Komudi Singh (Bethesda, MD, USA)
      How fasting impacts immunity – A bioinformatic approach to identify regulatory pathways in the modulation on CD4+ T cell activation

      P2.25 · Magdalena A. Zabielska (Gdansk, Poland)
      4-pirydone-3-carboxamide-1β-D-ribonucleoside (4PYR) – a novel endogenous endothelial toxin that disrupts cellular energetics

      P2.26 · Alice P. Sowton (Cambridge, United Kingdom)
      Lipid metabolism in the obese and hypoxic rat heart

      P2.27 · Maxime Tremblay-Gravel (Palo Alto, CA, USA)
      Lipidomic analyses show distinct perturbations in fatty acid metabolism in patients with pulmonary hypertension due to left heart disease

      P2.28 · Nirmal Verma (Lexington, KY, USA)
      Amylin dyshomeostasis – novel therapeutic target to limit hypoxia in diabetes

      P2.29 · George S.B. Williams (Baltimore, MD, USA)
      Tubulin-dependent regulation of metabolism in heart

      P2.30 · Yuan Zhang (Iowa City, IA, USA)
      Untargeted metabolomics analysis identifies a-hydroxyglutarate as a signature of human heart failure

      P2.31 · Allison Meadows (Cambridge, United Kingdom)
      Investigating the beneficial effects of fasting on cardiovascular health: a systems biology approach